The All New This Old South

Recent claims concerning the rise of the Sunbelt closely resemble those previously made about the New South. It is assumed that the South has finally broken the ties of dependency with the North and has embarked on a remarkable path of self-sustained growth. In fact, this growth in the South is considered to be largely at the expense of the North. These and other similar claims are based on five assumptions about the South: 1) An economic transformation has occurred in the region; 2) absentee ownership is minimal; 3) benefits of economic growth has been diffused to most segments of the population; 4) economic growth has reduced poverty and inequality in the region; and 5) government spending has spurred much of the region\u27s growth. These assumptions form the basis of the diffusion model of economic-industrial development. Examining these assumptions in light of available data, however, places in question the validity of claims made about the Sunbelt

Temporary employment and strategic staffing in the manufacturing sector

While prior research has identified different ways of using temporary workers to achieve numerical flexibility, quantitative analysis of temporary employment has been limited to a few key empirical indicators of demand variability that may confound important differences. Our analysis provides evidence that many manufacturers use temporary workers to achieve what we call planned and systematic numerical flexibility rather than simply in a reactive manner to deal with unexpected problems. Although temporary work may provide many benefits for employers, a key function appears to be the provision of numerical flexibility not to buffer core workers but to externalize certain jobs. © 2009 Regents of the University of California

Effectiveness of community outreach and engagement in recruitment success for a prebirth cohort.

IntroductionWe describe the effectiveness of community outreach and engagement in supporting recruitment for the US National Children's Vanguard Study between 2009 and 2012.MethodsThirty-seven study locations used 1 of 4 strategies to recruit 18-49-year-old pregnant or trying to conceive women: (1) Initial Vanguard Study used household-based recruitment; (2) Direct Outreach emphasized self-referral; (3) Enhanced Household-Based Recruitment enhanced Initial Vanguard Study strategies; and (4) Provider-Based Recruitment recruited through healthcare providers. Outreach and engagement included advance letters, interactions with healthcare providers, participation in community events, contacts with community organizations, and media outreach.ResultsAfter 1-2 years, 41%-74% of 9844 study-eligible women had heard about the National Children's Vanguard Study when first approached. Women who heard were 1.5-3 times more likely to consent. Hearing via word-of-mouth or the media most frequently predicted consent. The more sources women heard from the higher the odds of consent.ConclusionsWe conclude that tailored outreach and engagement facilitate recruitment in cohort studies

Greenhouse gas production in degrading ice-rich permafrost deposits in northeastern Siberia

Permafrost deposits have been a sink for atmospheric carbon for millennia. Thaw-erosional processes, however, can lead to rapid degradation of ice-rich permafrost and the release of substantial amounts of organic carbon (OC). The amount of the OC stored in these deposits and their potential to be microbially decomposed to the greenhouse gases carbon dioxide (CO2) and methane (CH4) depends on climatic and environmental conditions during deposition and the decomposition history before incorporation into the permafrost. Here, we examine potential greenhouse gas production in degrading ice-rich permafrost deposits from three locations in the northeast Siberian Laptev Sea region. The deposits span a period of about 55 kyr from the last glacial period and Holocene interglacial. Samples from all three locations were incubated under aerobic and anaerobic conditions for 134 days at 4 °C. Greenhouse gas production was generally higher in deposits from glacial periods, where 0.2–6.1% of the initially available OC was decomposed to CO2. In contrast, only 0.1–4.0% of initial OC were decomposed in permafrost deposits from the Holocene and the late glacial transition. Within the deposits from the Kargin interstadial period (Marine Isotope Stage 3), local depositional environments, especially soil moisture, also affected the preservation of OC. Sediments deposited under wet conditions contained more labile OC and thus produced more greenhouse gases than sediments deposited under drier conditions. To assess the greenhouse gas production potentials over longer periods, deposits from two locations were incubated for a total of 785 days. However, more than 50% of total CO2 production over 785 days occurred within the first 134 days under aerobic conditions while even 80% were produced over the same period under anaerobic conditions, which emphasizes the non-linearity of the OC decomposition processes. Methanogenesis was generally observed in active layer samples but only sporadically in permafrost samples and was several orders of magnitude smaller than CO2 production

Design, Fabrication, and Experimental Demonstration of Junction Surface Ion Traps

We present the design, fabrication, and experimental implementation of surface ion traps with Y-shaped junctions. The traps are designed to minimize the pseudopotential variations in the junction region at the symmetric intersection of three linear segments. We experimentally demonstrate robust linear and junction shuttling with greater than one million round-trip shuttles without ion loss. By minimizing the direct line of sight between trapped ions and dielectric surfaces, negligible day-to-day and trap-to-trap variations are observed. In addition to high-fidelity single-ion shuttling, multiple-ion chains survive splitting, ion-position swapping, and recombining routines. The development of two-dimensional trapping structures is an important milestone for ion-trap quantum computing and quantum simulations.Comment: 9 pages, 6 figure

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials

Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients who did not achieve an SVR. Methods: Population sequence analysis of the NS3•4A region was performed in patients who did not achieve SVR with TVR-based treatment. Results: Resistant variants were observed after treatment with a telaprevir-based regimen in 12% of treatment-naïve patients (ADVANCE; T12PR arm), 6% of prior relapsers, 24% of prior partial responders, and 51% of prior null responder patients (REALIZE, T12PR48 arms). NS3 protease variants V36M, R155K, and V36M+R155K emerged frequently in patients with genotype 1a and V36A, T54A, and A156S/T in patients with genotype 1b. Lower-level resistance to telaprevir was conferred by V36A/M, T54A/S, R155K/T, and A156S variants; and higher-level resistance to telaprevir was conferred by A156T and V36M+R155K variants. Virologic failure during telaprevir treatment was more common in patients with genotype 1a and in prior PR nonresponder patients and was associated with higher-level telaprevir-resistant variants. Relapse was usually associated with wild-type or lower-level resistant variants. After treatment, viral populations were wild-type with a median time of 10 months for genotype 1a and 3 weeks for genotype 1b patients. Conclusions: A consistent, subtype-dependent resistance profile was observed in patients who did not achieve an SVR with telaprevir-based treatment. The primary role of TVR is to inhibit wild-type virus and variants with lower-levels of resistance to telaprevir. The complementary role of PR is to clear any remaining telaprevir-resistant variants, especially higher-level telaprevir-resistant variants. Resistant variants are detectable in most patients who fail to achieve SVR, but their levels decline over time after treatment